Azetidine derivatives as inhibitors of stearoyl-coenzyme a...

Details Azetidine derivatives as inhibitors of stearoyl-coenzyme a... Azetidine derivatives as inhibitors of stearoyl-coenzyme a...

C - Chemistry, Metallurgy

07

D

C07D 403/04 (2006.01) A61K 31/497 (2006.01) A61P 3/00 (2006.01) C07D 401/14 (2006.01) C07D 403/14 (2006.01) C07D 409/14 (2006.01) C07D 417/14 (2006.01)

Patent

CA 2739466

Azetidine derivatives of structural formula I are inhibitors of stearoyl- coenzyme A delta-9 desaturase (SCD). The compounds of the present invention are useful for the prevention and treatment of conditions related to abnormal lipid synthesis and metabolism, including cardiovascular disease; atherosclerosis; obesity; diabetes; neurological disease; Metabolic Syndrome; insulin resistance; cancer; liver steatosis; and non-alcoholic steatohepatitis.

L'invention porte sur des dérivés d'azétidine, représentés par la formule de structure I, qui sont des inhibiteurs de la stéaroyl-coenzyme A delta-9 désaturase (SCD). Les composés de la présente invention sont utiles pour la prévention et le traitement d'affections liées à une synthèse et à un métabolisme anormaux des lipides, comprenant les  maladies cardiovasculaires; l'athérosclérose; l'obésité; le diabète; les maladies neurologiques; un syndrome métabolique; l'insulinorésistance; le cancer; la stéatose hépatique, et la stéatose hépatique non alcoolique.

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