Substituted 4-amino-2-arylcyclopenta[d]pyrimidines, their...

Details Substituted 4-amino-2-arylcyclopenta[d]pyrimidines, their... Substituted 4-amino-2-arylcyclopenta[d]pyrimidines, their...

C - Chemistry, Metallurgy

07

D

C07D 239/70 (2006.01) A61K 31/517 (2006.01) C07D 401/12 (2006.01)

Patent

CA 2351488

The present invention relates to compounds of formula (I) wherein R1, R2 and R3 have the meanings given in the claims. Said compounds are valuable active agents in medicaments for the treatment and prophylaxis of diseases, for example cardiovascular diseases such as hypertension, angina pectoris, heart failure, thrombosis and atherosclerosis. The compounds of formula (I) are able to modulate the body's own production of cyclic guanosine monophosphate (cGMP) and are generally suitable for the treatment and prophylaxis ofisorders associated with an impaired cGMP balance. The invention also relates to methods for producing compounds of formula (1), to their use in the treatment and prophylaxis of the above diseases and in the preparation of medicaments for such diseases, and to pharmaceutical preparations containing the compounds of formula (I).

L'invention concerne des composés de formule (I), dans laquelle R<1>, R<2> et R<3> ont les significations données dans les revendications, ces composés constituant des matières actives de valeur pour médicaments pour le traitement et la prophylaxie de maladies, par exemple, d'affections circulatoires telles que hypertension, angine de poitrine, insuffisance cardiaque, thromboses ou athérosclérose. Les composés de formule (I) sont aptes à moduler la production, spécifique au corps humain, de monophosphate de guanosine cyclique (cGMP) et conviennent, de façon générale, pour le traitement et la prophylaxie d'états morbides liés à un métabolisme cGMP perturbé. L'invention concerne en outre un procédé de fabrication des composés de formule (I), leur utilisation pour le traitement et la prophylaxie des états morbides précités et pour la fabrication de médicaments y relatifs, ainsi que des préparations pharmaceutiques renfermant lesdits composés de formule (I).

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