Therapeutic device for the selective cytoreduction treatment...

A - Human Necessities – 61 – F

Patent

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A61F 2/04 (2006.01) A61F 2/06 (2006.01) A61M 31/00 (2006.01) A61B 17/00 (2006.01) A61F 2/00 (2006.01)

Patent

CA 2194878

Therapeutic device (1) for the selective cytoreduction treatment of an obstruction in a natural lumen or passage (2) of the human or animal body, wherein said lumen is obstructed by the localised proliferation of cells, and said device comprises a normally cylindrical tubular element (3) to be located within said natural lumen, which is flexible enough to conform to said natural lumen but rigid enough to provide an artificial channel (4) within said lumen. The tubular element (3) supports lengthwise a medicinal sleeve (7) for registration and engagement with said obstruction once the tube has been located, and arranged for local delivery, at least in its outer surface portion, of one or more cytoreduction, in particular cytotoxic, therapeutic agents, by contacting the cells obstructing said lumen (2).

Dispositif (1) thérapeutique destiné au traitement cytoréducteur sélectif de l'obstruction d'une lumière ou voie naturelle (2) d'un corps humain ou animal, ladite lumière étant obstruée sous l'effet d'une prolifération cellulaire locale, ledit dispositif comprenant un élément tubulaire (3) destiné à être placé dans ladite lumière naturelle, notamment de forme cylindrique, suffisamment souple pour se conformer à ladite lumière naturelle, mais suffisamment rigide pour maintenir un passage artificiel (4) dans ladite lumière. L'élément tubulaire (3) supporte selon sa longueur un manchon médicamenteux (7), destiné à venir en regard et au contact de l'obstruction une fois la lumière naturelle intubée, et agencé pour délivrer localement, au moins dans sa partie superficielle externe, au moins un agent thérapeutique cytoréducteur, notamment cytotoxique par contact avec les cellules sous l'effet desquelles ladite lumière (2) est obstruée.

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