C - Chemistry – Metallurgy – 07 – D
Patent
C - Chemistry, Metallurgy
07
D
C07D 221/16 (2006.01) A61K 31/495 (2006.01) A61P 35/00 (2006.01) C07D 401/04 (2006.01) C07D 401/14 (2006.01)
Patent
CA 2637572
Disclosed are compounds of the formula: wherein R13 represents an imidazole ring; R14 represents a carbamate, urea, amide or sulfonamide group, and the remaining substituents are as defined herein. Also disclosed is a method of treating cancer and a method of inhibiting farnesyl protein transferase using the disclosed compounds.
La présente invention concerne des composés de formule où R13 représente un cycle imidazole ; R14 représente un groupement carbamate, urée, amide ou sulfonamide, et les substituants restants sont tels que définis dans la présente invention. La présente invention concerne également une méthode de traitement du cancer et une méthode d'inhibition de la farnésyl transférase en utilisant les composés décrits.
Afonso Adriano
Kelly Joseph M.
Ogilvy Renault Llp/s.e.n.c.r.l.,s.r.l.
Schering Corporation
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