C - Chemistry – Metallurgy – 07 – D
Patent
C - Chemistry, Metallurgy
07
D
C07D 337/04 (2006.01) C07D 337/06 (2006.01) C07D 409/04 (2006.01) C07D 495/04 (2006.01) C07K 17/02 (2006.01) C12N 9/99 (2006.01) C12Q 1/37 (2006.01)
Patent
CA 2203570
Tri- and tetra substituted thiepane compositions having use as immunogens, therapeutics, diagnostics and for other industrial purposes are disclosed. The compositions inhibit proteolytic activity of viral enzymes and are useful for the inhibition of such enzymes as well as in assays for the detection of such enzymes. Embodiments in which antigenic polypeptides are bonded to the compositons are useful in raising antibodies against the thiepane haptens or the polypeptide. Labeled thiepanes of this invention are useful as diagnostic reagents.
L'invention concerne des compositions de thiépanes tri- et tétrasubstitués utiles comme immunogènes, agents thérapeutiques, agents diagnostiques, ainsi que dans d'autres applications industrielles. Ces compositions inhibent l'activité protéolytique d'enzymes virales et elles sont utiles pour inhiber de telles enzymes ainsi que pour les détecter. Les formes d'exécution où des polypeptides antigéniques sont liés à un composé de l'invention sont utiles pour provoquer la formation d'anticorps contre l'haptène thiépane ou contre le polypeptide. Des thiépanes marqués de cette invention sont utiles comme agents diagnostiques.
Bischofberger Norbert W.
Kim Choung U.
Krawczyk Steven H.
Mcgee Lawrence R.
Postich Michael J.
Gilead Sciences Inc.
Robic
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