Boris isoforms and methods of detecting and treating disease

C - Chemistry – Metallurgy – 12 – N

Patent

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Details

C12N 15/12 (2006.01) G06F 19/28 (2011.01) A61K 31/713 (2006.01) A61K 39/00 (2006.01) A61K 39/395 (2006.01) A61P 35/00 (2006.01) A61P 37/04 (2006.01) C07K 14/47 (2006.01) C07K 16/18 (2006.01) C12Q 1/68 (2006.01) C40B 40/06 (2006.01) C40B 40/10 (2006.01) G01N 33/53 (2006.01) G01N 33/564 (2006.01) G01N 33/574 (2006.01) G01N 33/68 (2006.01)

Patent

CA 2662012

A method of detecting a proliferative disease, such as a disease associated with the abnormal expression of BORIS, in a mammal comprising testing for the expression of a BORIS isoform in the tissue of a mammal that does not express BORIS in the absence of disease, as well as a method of treating or preventing such a disease, isolated or purified BORIS isoform polypeptides and nucleic acids, and kits and arrays comprising same.

La présente invention concerne un procédé de détection d'un trouble prolifératif, tel qu'une maladie associée à l'expression anormale de BORIS, chez un mammifère comprenant un essai de l'expression d'une isoforme de BORIS dans le tissu d'un mammifère qui n'exprime pas BORIS en l'absence d'une maladie, ainsi qu'un procédé de traitement ou de prévention d'une telle maladie, des polypeptides et des acides nucléiques d'isoforme de BORIS isolés ou purifiés, et des kits et des matrices comprenant ceux-ci.

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