Sulfonamide matrix metalloproteinase inhibitors

Details Sulfonamide matrix metalloproteinase inhibitors Sulfonamide matrix metalloproteinase inhibitors

C - Chemistry, Metallurgy

07

D

C07D 417/12 (2006.01) A61K 31/18 (2006.01) A61K 31/541 (2006.01) A61P 19/02 (2006.01) A61P 35/00 (2006.01) C07D 279/12 (2006.01) C07D 417/14 (2006.01) C07F 9/00 (2006.01)

Patent

CA 2371481

-54- Matrix metalloproteinase inhibitors are tricyclic substituted cyclic sulfonamides of the formula Image or a pharmaceutically acceptable salt thereof wherein R1 and R2 include hydrogen, alkyl, and substituted alkyl; R3 and R4 include hydrogen, halo, and alkyl; X is OH or NHOH, V is O, S, SO2, NR5, or CH2, R5 is a hydrogen or alkyl, and Z is (CH2)n, wherein n is an integer from 0 to 2.

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