Stabilized medicinal aerosol solution formulation

Details Stabilized medicinal aerosol solution formulation Stabilized medicinal aerosol solution formulation

A - Human Necessities

61

K

A61K 9/12 (2006.01) A61K 9/00 (2006.01) A61K 9/08 (2006.01) A61K 31/135 (2006.01) A61K 31/395 (2006.01) A61K 31/46 (2006.01) A61K 47/10 (2006.01)

Patent

CA 2151383

Stabilized medicinal aerosol solution formulations comprising medicaments that degrade or decompose by interaction with solvents or water, an HFC propellent, a cosolvent and an acid are described. Further, specific medicinal aerosol solution formulations comprising ipratropium bromide or fenoterol, ethyl alcohol, 1,1,1,2-tetrafluoroethane or 1,1,1,2,3,3,3-heptafluoropropane, and either an inorganic acid or an organic acid are described. The acids ace present in amounts sufficient to reduce the degradation of the medicaments to acceptable levels.

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