Remedies for arthritis deformans and remedies for rheumatoid...

A - Human Necessities – 61 – K

Patent

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A61K 38/17 (2006.01) A61K 31/711 (2006.01) A61K 38/57 (2006.01) A61K 48/00 (2006.01) A61P 19/02 (2006.01) A61P 29/00 (2006.01) A61P 43/00 (2006.01) C07K 14/47 (2006.01) C07K 14/50 (2006.01) C07K 14/51 (2006.01) C12N 15/09 (2006.01) A61K 38/00 (2006.01)

Patent

CA 2439653

It is intended to provide remedies efficacious for arthritis deformans and rheumatoid arthritis. Namely, remedies for arthritis deformans and rheumatoid arthritis which contain, as the active ingredient, chondromodulin-I protein having an activity of proliferating articular cartilage cells either alone or in the coexistence with a basic fibroblast growth factor and an activity of inhibiting accelerated degradation of cartilage matrix.

L'invention concerne des remèdes efficaces pour l'arthrite déformante et pour l'arthrite rhumatoïde. Elle concerne en particulier des remèdes pour l'arthrite déformante et pour l'arthrite rhumatoïde qui contiennent, en tant que principe actif, une protéine chondromuduline-I qui possède une activité favorisant la prolifération de cellules de cartilage articulaire, soit seule ou soit en conjonction avec un facteur de croissance de fibroblastique de base, ainsi qu'une activité d'inhibition de la dégradation accélérée de la matrice cartilagineuse.

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