Antibodies with immune effector activity and that...

Details Antibodies with immune effector activity and that... Antibodies with immune effector activity and that...

C - Chemistry, Metallurgy

12

N

C12N 15/13 (2006.01) A61K 39/395 (2006.01) A61K 47/48 (2006.01) A61K 51/10 (2006.01) A61P 35/00 (2006.01) C07K 16/28 (2006.01) C07K 16/30 (2006.01) C12N 5/10 (2006.01) C12N 15/63 (2006.01) C12P 21/08 (2006.01) G01N 33/569 (2006.01) G01N 33/574 (2006.01)

Patent

CA 2607444

This invention relates to the use of monoclonal and polyclonal antibodies that specifically bind to and have the ability in the alternative to become internalized by cells expressing folate receptor alpha (FRA) and to induce an immune effector activity such as antibody-dependent cellular cytotoxicity. The antibodies are useful in specific delivery of pharmacologic agents to FRA- expressing cells as well as in eliciting an immune-effector activity particularly on tumor cells and precursors. The invention is also related to nucleotides encoding the antibodies of the invention, cells expressing the antibodies; methods of detecting cancer cells; and methods of treating cancer using the antibodies.

La présente invention concerne l'utilisation d'anticorps monoclonaux et polyclonaux qui se lient de manière spécifique à des cellules exprimant un récepteur de folate alpha (FRA) et qui ont la possibilité de devenir internalisés par ces cellules et d'induire une activité d'effecteur immunitaire telle qu'une cytotoxicité cellulaire dépendante de l'anticorps. Ces anticorps sont utilisés pour délivrer de manière spécifique des agents pharmacologiques à des cellules exprimant FRA et pour déclencher une activité d'effecteur immunitaire particulièrement sur des cellules tumorales et des précurseurs. Cette invention concerne également des nucléotides codant lesdits anticorps, des cellules exprimant lesdits anticorps, des procédés pour détecter des cellules cancéreuses, ainsi que des procédés pour traiter un cancer en utilisant lesdits anticorps.

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