Substituted pyrimido [2, 1-a] isoquinolin-4-one derivatives

Details Substituted pyrimido [2, 1-a] isoquinolin-4-one derivatives Substituted pyrimido [2, 1-a] isoquinolin-4-one derivatives

C - Chemistry, Metallurgy

07

D

C07D 471/04 (2006.01) A61K 31/519 (2006.01) A61P 17/14 (2006.01) A61P 25/00 (2006.01) A61P 31/10 (2006.01)

Patent

CA 2728693

A pyrimido isoquinoline derivative represented by formula (I) : wherein: R1 represents a 4-pyridine ring or a 4--pyrimidine ring; R2 represents a hydrogen atom: R3 represents a hydrogen atom; R4 represents: a hydrogen atom; a halogen atom; R7, RB, R9. R10 represent independently from each other a hydrogen atom, a halogen atom, a C1-6 alkoxy group, a nitro, a hydroxyl or an amino; Formula (II) represents a single or a double bond, in form of a free base or of an addition salt with an acid. The compounds of formula (I) are useful for the treatment of neurodegenerative diseases caused by abnormal activity of GSK3.beta..

La présente invention concerne des composés de formule (I) dans laquelle: R1 représente un noyau 4-pyridine ou un noyau 4-pyrimidine; R2 représente un atome dhydrogène; R3 représente un atome dhydrogène; R4 représente un atome dhydrogène, un atome dhalogène; R7, R8, R9, R10 représentent indépendamment les uns des autres un atome dhydrogène, un atome dhalogène, un groupe Ci-ß alcoxy, nitro, hydroxy ou amino; - représente une liaison simple ou double, sous la forme dune base libre ou dun sel daddition à un acide. Les composés de formule (I) sont utiles pour le traitement de maladies neurodégénératives provoquées par une activité anormale du GSK3ß.

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