A - Human Necessities – 61 – K
Patent
A - Human Necessities
61
K
A61K 38/50 (2006.01) A61P 31/14 (2006.01)
Patent
CA 2574719
We conducted feline calicivirus (FCV) inhibition experiment with two anti- viral aminohydrolases, asparaginase and glutaminase. We found that in the presence of 8 units and 4 units/ml of asparaginase, about 90% of FCV replication was inhibited. In contrast, glutaminase showed no significant inhibition effect on the virus replication. We have also shown that asparaginase did not inhibit the replication of adenovirus suggesting that the inhibition was specific. Our results implicated that asparaginase could be used as a candidate for anti-FCV drug development.
Une expérience d'inhibition du calicivirus félin (FCV) a été effectuée avec deux aminohydrolases, l'asparaginase et la glutaminase. Il a été observé qu'en la présence de 8 unités et 4 unités/ml d'asparaginase, la réplication de FCV a été inhibée à environ 90 %. Au contraire, la glutaminase n'a présenté aucun effet d'inhibition significatif sur la réplication du virus. Il a aussi été démontré que l'asparaginase n'a pas entraîné l'inhibition de la réplication d'adénovirus indiquant que l'inhibition était spécifique. Les résultats de l'expérience impliquent que l'asparaginase pourrait être utilisée pour le développement d'un médicament contre le FCV.
Battison Williams Dupuis
Her Majesty The Queen In Right Of Canada As Represented By The Minister Of Health Canada
LandOfFree
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