Pharmaceutical compositions comprising higher primary...

A - Human Necessities – 61 – K

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A61K 31/366 (2006.01) A61K 31/045 (2006.01) A61K 31/40 (2006.01) A61P 3/00 (2006.01)

Patent

CA 2553988

A novel pharmaceutical composition comprising a mixture of higher primary aliphatic alcohols from (24) to (39) carbon atoms; at least one another component selected from resins and pigments, hydrocarbons, esters, ketones and aldehydes, and phenolic compounds, and HMG CoA reductase inhibitor, its salts, analogs or derivatives thereof, preferably statins, optionally with pharmaceutically acceptable excipients, and process of preparation of such composition is provided. Also provided are method of treatment and use of such composition for reducing abnormal lipid parameters associated with hyperlipidemia.

La présente invention concerne une nouvelle composition pharmaceutique comprenant un mélange d'alcools aliphatiques hautement primaires comprenant de 22 à 39 atomes de carbone, au moins un autre de composant sélectionné parmi des résines, des pigments, des glucides, des esters, des cétones et des aldéhydes et, des composés phéniliques et un inhibiteur de réductase HMG CoA, des sels, des analogues ou des dérivés de ceux-ci, de préférence des statines, éventuellement avec des excipients répondant aux normes pharmaceutiques et, un processus de préparation de cette composition. Cette invention concerne aussi une technique de traitement et d'utilisation de cette composition destinée à réduire les paramètres lipidiques anormaux associés à l'hyperlipidémie.

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