Retroviral vectors for expression in embryonic cells

Details Retroviral vectors for expression in embryonic cells Retroviral vectors for expression in embryonic cells

C - Chemistry, Metallurgy

12

N

C12N 15/86 (2006.01) A61K 31/70 (2006.01) A61K 35/12 (2006.01) A61K 48/00 (2006.01) C07K 14/15 (2006.01) C12N 5/10 (2006.01) C12N 15/11 (2006.01) C12N 15/85 (2006.01) C12N 15/867 (2006.01)

Patent

CA 2208210

Retroviral plasmid vectors which include an enhancer region obtained from a virus selected from the group consisting of Myeloproliferative Sarcoma Virus and polyoma virus, and a primer binding site obtained from murine retrovirus. The retroviral plasmid vector does not include a negative control region. The vector also may include a nucleic acid sequence which encodes demethylation of cytosine residues in the proviral LTR. Such plasmid vectors are especially useful in the generation of retroviral vector particles which may be expressed in embryonic cells, such as embryonic stem cells.

Vecteurs plasmidiques rétroviraux comportant une zone activatrice obtenue d'un virus choisi dans le groupe composé du virus du sarcome myéloprolifératif et du virus du polyome, ainsi qu'un site de liaison avec l'amorce obtenu à partir du rétrovirus murin. Les vecteurs plasmidiques rétroviraux ne comprennent pas de zone témoin négative. Les vecteurs peuvent aussi inclure une séquence nucléotidique qui code la déméthylation de restes de la cytosine dans la longue répétition terminale du provirus. Ces vecteurs plasmidiques sont particulièrement utiles pour la production de particules de vecteurs rétroviraux pouvant s'exprimer dans des cellules embryonnaires telles que les cellules souche embryonnaires.

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