A - Human Necessities – 61 – K
Patent
A - Human Necessities
61
K
A61K 38/20 (2006.01) A61K 47/48 (2006.01) A61P 35/00 (2006.01)
Patent
CA 2628756
The present invention provides methods for the treatment and/or prevention of thrombocytopenia including thrombocytopenia associated with drug-induced liver damage and thrombocytopenia associated with drug-induced bone marrow destruction. The methods of treatment of the invention include administration of interleukin-11 to a subject suffering from or susceptible to thrombocytopenia and/or receiving or about to receive a treatment involving a conjugate therapeutic agent whose administration results in thrombocytopenia. Also provided are pharmaceutical compositions and kits useful for carrying out such methods of treatment.
La présente invention concerne des procédés pour le traitement et/ou la prévention d'une thrombocytopénie, y compris une thrombocytopénie associée à une lésion du foie d'origine médicamenteuse et une thrombocytopénie associée à la destruction d'origine médicamenteuse de la moelle osseuse. Les procédés de traitement de l'invention consistent à administrer l'interleukine-11 à un sujet souffrant de thrombocytopénie ou prédisposé à une thrombocytopénie et/ou recevant ou étant sur le point de recevoir un traitement comprenant un agent thérapeutique conjugué dont l'administration entraîne une thrombocytopénie. L'invention concerne également des compositions pharmaceutiques et des kits utiles pour effectuer de tels procédés de traitement.
Damle Nitin K.
Dijoseph John
Schendel Paul F.
Torys Llp
Wyeth
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