Phenylaliphatylaminoalkanediphosphonic acids

Details Phenylaliphatylaminoalkanediphosphonic acids Phenylaliphatylaminoalkanediphosphonic acids

C - Chemistry, Metallurgy

07

F

167/260, 260/501

C07F 9/38 (2006.01) A61K 31/66 (2006.01)

Patent

CA 2003766

4- 17340/+ Phenylaliphatylaminoalkanediphosphonic acids Abstract Phenylaliphatylaminoalkanediphosphonic acids of the formula Image (I) in which R1 is an aliphatic hydrocarbon radical having 4 and not more than 7 C atoms and substituted by phenyl, R2 is A monovalent aliphatic hydrocarbon radical having 1 and not more than 4 C atoms and alk is a divalent aliphatic hydrocarbon radical having 2 and not more than 4 C atoms, and their salts, have a particularly pronounced regulating action on calcium metabolism and can be used as medicaments for the treatment of diseases to be attributed to disturbances thereof. They are prepared, for example, by reacting a compound of the formula (V) Image in which X3 denotes carboxyl, with a phosphorylating agent and hydrolyzing the primary product.

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