A - Human Necessities – 61 – K
Patent
A - Human Necessities
61
K
A61K 47/26 (2006.01) A61K 47/14 (2006.01) A61K 47/20 (2006.01)
Patent
CA 2714514
The present invention provides a novel liquid composition suitable for in-situ formation of a depot system to deliver a bioactive substance in a controlled manner. The composition of the present invention comprises: (a) a hydrophobic non-polymeric carrier material; (b) a water miscible biocompatible organic solvent that dissolves the hydrophobic non-polymeric material; (c) an ionic complex that is formed between an amphiphilic molecule and a bioactive substance having a net charge at neutral pH in water. The present invention also provides a method of manufacturing and use of the composition thereof.
L'invention concerne une nouvelle composition liquide appropriée pour la formation in situ d'un système de dépôt pour administrer une substance bioactive de manière contrôlée. La composition de la présente invention comprend : (a) un matériau porteur non polymère hydrophobe; (b) un solvant organique biocompatible miscible dans l'eau qui dissout le matériel non polymère hydrophobe; (c) un complexe ionique qui est formé entre une molécule amphiphile et une substance bioactive ayant une charge nette à pH neutre dans de l'eau. La présente invention fournit également un procédé de fabrication et d'utilisation de la composition correspondante.
Chien Benjamin
Guarino Andrew
Li Yuhua
Moffat & Co.
Qps Llc
LandOfFree
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