C - Chemistry – Metallurgy – 12 – Q
Patent
C - Chemistry, Metallurgy
12
Q
C12Q 1/00 (2006.01) G01N 33/68 (2006.01)
Patent
CA 2629923
The invention relates to a method of measuring the immunological activity of a vaccine preparation in the form of a mixture of one or more allergenic enzyme(s) and an oxygen- containing metal salt adjuvant, wherein the mixture comprises a liquid phase and a solid phase, and wherein at least a part of the allergenic enzyme(s) is adsorbed to the solid phase, the method comprising the steps of measuring the enzymatic activity of the mixture in an enzyme activity assay, and using the measurement obtained as an indication of the immunological activity of the vaccine preparation, or using the measurement obtained for quantifying the amount of allergenic enzyme.
L~invention concerne un procédé de mesure de l~activité immunologique d~une préparation de vaccin sous forme d~un mélange d~une ou de plusieurs enzymes allergéniques et d~un adjuvant de sel métallique contenant de l~oxygène, ledit mélange comprenant une phase liquide et une phase solide et au moins une partie de l'enzyme ou des enzymes allergéniques est adsorbée à la phase solide , ledit procédé comprenant les étapes suivantes : mesurer l~activité enzymatique du mélange lors d~une analyse de l~activité enzymatique et utiliser la mesure obtenue en tant qu~indication de l~activité immunologique de la préparation de vaccin, ou utiliser la mesure obtenue pour quantifier la quantité d'enzymes allergéniques.
Ferreras Gomez Maria Mercedes
Ipsen Hans-Henrik
Krogh Rasmus Linnemann
Maltesen Morten Jonas
Alk-Abello A/s
Norton Rose Or S.e.n.c.r.l. S.r.l./llp
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