Use of antimicrobial agent such as taurolidine or taurultam...

A - Human Necessities – 61 – K

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Details

A61K 31/549 (2006.01) A61P 31/04 (2006.01) A61K 9/02 (2006.01) A61K 9/08 (2006.01) A61K 9/10 (2006.01) A61K 9/20 (2006.01) A61K 9/48 (2006.01)

Patent

CA 2317748

The invention provides a method and composition for treatment of a nosocomial, microbial infection of a patient which comprises introduction into the gut of a patient an antimicrobial amount of an antimicrobial medicament which is cell wall constituent-inactivating, endotoxin non-releasing, exotoxin inactivating or a combination thereof. In particular, the invention provides the use of Taurolidine and/or Taurultam in the treatment of multi-resistant infections, e.g. VRE and MRSA.

L'invention concerne une méthode et une composition pour traiter une infection microbienne, nosocomiale chez un patient. Cette méthode consiste à introduire dans le tube digestif d'un patient une quantité à effet antimicrobien d'un médicament antimicrobien choisi parmi les médicaments antimicrobiens qui inactivent les constituants de parois cellulaires, ne libèrent pas d'endotoxines, inactivent les exotoxines, ou d'une combinaison de ces médicaments. L'invention concerne en particulier l'utilisation de taurolidine et/ou de taurultame dans le traitement d'infections multirésistantes, telles que VRE (entérocoque résistant à la vancomycine) et MRSA (staphylocoque doré résistant à la méthicilline).

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