Methods of optimizing antibody variable region binding affinity

Details Methods of optimizing antibody variable region binding affinity Methods of optimizing antibody variable region binding affinity

C - Chemistry, Metallurgy

07

K

C07K 16/46 (2006.01) C07K 16/00 (2006.01) C07K 16/28 (2006.01) C12N 15/09 (2006.01) C40B 30/04 (2006.01) G01N 33/53 (2006.01) C12N 15/13 (2006.01)

Patent

CA 2387267

The invention provides a method of conferring donor CDR binding affinity onto an antibody acceptor variable region framework. The invention also provides a method of simultaneously grafting and optimizing the binding affinity of a variable region binding fragment. A method of optimizing the binding affinity of an antibody variable region is also provided. The variable region populations can be heavy or light chains and can be expressed as individual populations or they can be coexpressed to produce heteromeric variable region binding fragments.

L'invention porte sur un procédé conférant à un CDR donneur une affinité de fixation à une structure de région variable d'un accepteur d'anticorps. L'invention porte également sur un procédé simultané de greffage et d'optimisation de affinité de fixation d'un fragment de fixation de région variable. L'invention porte en outre sur un procédé d'optimisation de affinité de fixation de la région variable d'anticorps. Les populations de la région variable peuvent être des chaînes lourdes ou légères et être exprimées en tant que populations individuelles, ou peuvent être coexprimées pour produire des fragments hétéromères de fixation de régions variables.

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