C - Chemistry – Metallurgy – 12 – N
Patent
C - Chemistry, Metallurgy
12
N
C12N 5/0789 (2010.01) C12N 5/071 (2010.01) C12N 5/0735 (2010.01) C12N 15/09 (2006.01) C12N 15/63 (2006.01) C12N 15/85 (2006.01) C12Q 1/02 (2006.01) C12Q 1/04 (2006.01) C12Q 1/68 (2006.01) G01N 33/569 (2006.01)
Patent
CA 2683056
The disclosure relates to a method of reprogramming one or more somatic cells, e.g., partially differentiated or fully/ terminally differentiated somatic cells, to a less differentiated state, e.g., a pluripotent or multipotent state. In further embodiments the invention also relates to reprogrammed somatic cells produced by methods of the invention, to uses of said cells, and to methods for identifying agents useful for reprogramming somatic cells.
La présente invention concerne un procédé permettant de reprogrammer une ou plusieurs cellules somatiques, par exemple des cellules somatiques partiellement différenciées ou totalement/définitivement différenciées, dans un état moins différencié, par exemple, un état pluripotent ou multipotent. Dans d'autres modes de réalisation, l'invention concerne également des cellules somatiques reprogrammées produites par les procédés de l'invention, des utilisations desdites cellules, et des procédés permettant d'identifier des agents utiles pour la reprogrammation de cellules somatiques.
Brambrink Oliver Tobias
Foreman Ruth
Grant Welstead G.
Hanna Jacob
Jaenisch Rudolf
Smart & Biggar
Whitehead Institute For Biomedical Research
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