Methods of modulating heme oxygenase-1 expression and...

A - Human Necessities – 61 – K

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A61K 48/00 (2006.01) A61K 9/127 (2006.01) A61K 31/7088 (2006.01) A61K 38/44 (2006.01) C12N 9/02 (2006.01) A61K 38/00 (2006.01)

Patent

CA 2473728

A method of modifying heme oxygenase-1 transcription is disclosed. The method includes modifying the nuclear concentration of biliverdin reductase, or fragments or variants thereof which bind to a heme oxygenase-1 regulatory sequence, in a cell, whereby an increase in the nuclear concentration of biliverdin reductase, or fragments or variants thereof, increases the transcription of heme oxygenase-1 and a decrease in the nuclear concentration of biliverdin reductase, or fragments or variants thereof, decreases the transcription of heme oxygenase-1.

La présente invention concerne un procédé pour modifier la transcription de la hème oxygénase-1. Le procédé comprend la modification de la concentration nucléaire de la biliverdine réductase, ou des fragments ou variantes de celle-ci qui se lient à une séquence de régulation de la hème oxygénase-1, dans une cellule, une augmentation de la concentration nucléaire de la biliverdine réductase, ou des fragments ou variantes de celle-ci provoquant une augmentation de la transcription de la hème oxygénase-1 et une diminution de la concentration nucléaire de la biliverdine réductase, ou des fragments ou variantes de celle-ci provoquant une diminution de la transcription de la hème oxygénase-1.

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