Protein c derivatives

Details Protein c derivatives Protein c derivatives

C - Chemistry, Metallurgy

12

N

C12N 9/64 (2006.01) A61K 38/48 (2006.01) C12N 15/57 (2006.01) A61K 38/00 (2006.01) A61K 48/00 (2006.01)

Patent

CA 2399267

Novel human protein C derivatives are described. These derivatives have increased anti-coagulation activity and resistance to inactivation by serpins compared to wild-type protein C and retain the biological activity of the wild- type human protein C. These derivatives will require either less frequent administration and/or smaller dosage than wild-type human protein C in the treatment of acute coronary syndromes, vascular occlusive disorders, hypercoagulable states, thrombotic disorders and disease states predisposing to thrombosis.

Nouveaux dérivés de protéine C humaine qui présentent une activité accrue d'anti-coagulation et une résistance accrue à l'inactivation par les serpines, comparés à la protéine C de type sauvage, et qui conservent l'activité biologique de la protéine C humaine de type sauvage. Ces dérivés exigent une administration moins fréquente et/ou un dosage plus faible que la protéine C humaine de type sauvage dans le traitement de syndromes coronariens aigus, de troubles vasculaires occlusifs, d'états d'hypercoagulation, de troubles thrombotiques et d'états pathologiques prédisposant à la thrombose.

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