A - Human Necessities – 61 – K
Patent
A - Human Necessities
61
K
A61K 47/48 (2006.01) A61K 31/7088 (2006.01) A61K 47/42 (2006.01) C07K 17/00 (2006.01) C12N 15/87 (2006.01)
Patent
CA 2523672
Compositions and methods for enhancing delivery of molecules, e.g. biological agents, into cells are described. The composition is a conjugate of the biological agent, preferably a nucleic acid analog having a substantially uncharged backbone, covalently linked to a peptide transporter moiety as described. Conjugation of the peptide transporter to a substantially uncharged nucleic acid analog, such as a morpholino oligomer, is also shown to enhance binding of the oligomer to its target sequence and enhance antisense activity.
L'invention concerne des compositions et des procédés pour améliorer l'administration des molécules, par exemple des agents biologiques, dans des cellules. Ladite composition est un conjugué de l'agent biologique, de préférence un analogue d'acide nucléique présentant un squelette non chargé, lié de manière covalente à une fraction de transporteur de peptide. La conjugaison du transporteur de peptide en un analogue d'acide nucléique sensiblement non chargé, tel qu'une morpholine oligomère, est également conçue pour améliorer la liaison de l'oligomère et de sa séquence cible et pour améliorer l'activité antisens.
Iversen Patrick L.
Kroeker Andrew D.
Moulton Hong M.
Nelson Michelle H.
Stein David A.
Avi Biopharma Inc.
Gowling Lafleur Henderson Llp
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