C - Chemistry – Metallurgy – 07 – H
Patent
C - Chemistry, Metallurgy
07
H
C07H 1/06 (2006.01) C07H 5/02 (2006.01)
Patent
CA 2620902
A process is described for extraction of 6- acyl - 4,1~, 6~ trichlorogalactosucrose abbreviated as TGS-6-ester from a process stream containing one or more of TGS-6-ester and impurities including DMF, requiring DMF removal, comprising neutralization of the process stream, adjustment of pH thereafter to acidic side, preferably between 5 to 7, followed by extraction with a partially miscible or immiscible organic solvent, optional concentration of the organic solvent extract, extraction of the organic solvent extracts with saturated aqueous salt solution to remove dimethylformamide (DMF) and isolation of TGS-6-acetate in a pure fraction which can be subjected to deacylation at alkaline pH to form TGS.
La présente invention concerne un processus d'extraction de 6- acyle - 4,1', 6' trichlorogalactosaccharose, abrégé en ester TGS-6 d'un flux de processus contenant un ou plusieurs esters TGS-6 et des impuretés comprenant DMF, nécessitant l'élimination du DMF. Ce processus comprend la neutralisation de ce flux de processus, le réglage du pH ensuite au côté acide, de préférence entre 5 et 7, suivi de l'extraction avec un solvant organique non miscible ou partiellement miscible, éventuellement la concentration de l'extrait de solvant organique, l'extraction des extraits de solvant organique avec une solution de sel aqueuse saturée destinée à éliminer le diméthylformamide (DMF) et l'isolation d'acétate TGS-6 dans une fraction pure qui peut être soumise à une désacylation à un pH alcalin pour former le TGS.
Aurora Sundeep
Gani Ramesh
Pattanshettar Raviraj S.
Ratnam Rakesh
Pharmed Medicare Pvt. Ltd.
Ridout & Maybee Llp
V. B. Medicare Private Limited
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