A - Human Necessities – 61 – K
Patent
A - Human Necessities
61
K
A61K 31/554 (2006.01) A61K 45/06 (2006.01) A61P 3/10 (2006.01)
Patent
CA 2422671
The invention provides compositions and methods for altering insulin secretion using an agent that inhibits calcium efflux via the mitochondrial calcium/ sodium antiporter (MCA). Methods of treatment are thereby provided, and are particularly useful for treatment of subjects having, or suspected of being at risk for having, diabetes mellitus. Compositions and methods related to the identification of gene sequences encoding the mitochondrial calcium/ sodium antiporter, expression of such sequences and screening assays using expressed MCA products are also provided.
L'invention concerne des compositions et des procédés permettant de modifier la sécrétion d'insuline à l'aide d'un agent qui inhibe la sortie du calcium par le biais de l'antiport calcium/sodium mitochondrial (MCA). L'invention concerne des procédés de traitement particulièrement utiles pour soigner des patients qui ont, ou qui présentent des risques d'avoir, le diabète sucré. L'invention concerne également des compositions et des procédés se rapportant à l'identification de séquences géniques codant l'antiport calcium/sodium mitochondrial, l'expression de telles séquences, ainsi que des essais de criblage utilisant des produits MCA exprimés.
Anderson Christen M.
Davis Robert E.
Ghosh Soumitra S.
Pei Yazhong
Gowling Lafleur Henderson Llp
Mitokor
LandOfFree
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