Substituted pyrrolopyrimidines and processes for their...

Details Substituted pyrrolopyrimidines and processes for their... Substituted pyrrolopyrimidines and processes for their...

C - Chemistry, Metallurgy

07

D

C07D 487/04 (2006.01) A61K 31/505 (2006.01) A61K 31/519 (2006.01) A61K 31/535 (2006.01)

Patent

CA 2262421

There are described 7H-pyrrolo[2,3-d] pyrimidine derivatives of formula (I) in which the substituents are as defined in claim 1. These compounds inhibit the tyrosine kinase activity of the receptor for the epidermal growth factor (EGF) and c-erbB2kinase and can be used as anti-tumour agents.

L'invention concerne des dérivés des 7H-pyrrolo(2,3-d)pyrimidine selon la formule (I), dans laquelle les substituents sont tels que définis dans la revendication 1. Ces composés inhibent l'activité de la tyrosine-kinase du récepteur pour le facteur de croissance épidermique et la kinase c-erbB2. Ainsi, ces composés peuvent être utilisés comme agents anti-tumoraux.

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