Method to detect bone and other connective tissue disorders...

Details Method to detect bone and other connective tissue disorders... Method to detect bone and other connective tissue disorders...

C - Chemistry, Metallurgy

07

K

C07K 16/00 (2006.01) C07K 16/18 (2006.01) G01N 33/53 (2006.01)

Patent

CA 2271544

The invention is directed to methods to assess connective tissue, especially bone, metabolism in disease or to monitor therapy, which method comprises assessing the levels of native free collagen-derived crosslinks in biological fluids, especially urine. The method can be enhanced by concomitantly determining the levels of an indicator of bone formation in biological fluids of the same individual and assessing the differences between the degradation marker and the formation indicator. Antibodies which are specifically immunoreactive with forms of crosslinks which occur free in biological fluids are also disclosed.

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