Substituted benzenedicarboxylic acid diguanides, process for...

Details Substituted benzenedicarboxylic acid diguanides, process for... Substituted benzenedicarboxylic acid diguanides, process for...

C - Chemistry, Metallurgy

07

C

C07C 279/22 (2006.01) A61K 31/16 (2006.01) A61K 31/275 (2006.01) A61K 31/33 (2006.01) A61K 49/00 (2006.01) C07C 311/47 (2006.01) C07C 317/32 (2006.01) C07C 323/44 (2006.01) C07D 207/36 (2006.01) C07D 213/65 (2006.01) C07D 215/20 (2006.01) C07D 233/70 (2006.01) C07D 307/58 (2006.01) C07D 333/32 (2006.01)

Patent

CA 2190693

Benzenedicarboxylic acid diguanides of the formula I Image I in which R(1) to R(5) have the meanings given in the claims, are useful antiarrhythmic pharmaceuticals having a cardioprotective component, even for the prevention of ischemically induced damage, in particular in the induction of ischemically induced cardiac arrhythmias. As a result of inhibition of the cellular Na+/H+ exchange mechanism, they are used for the treatment of acute or chronic damage caused by ischemia. Moreover, they are distinguished by potent inhibitory action on the proliferation of cells. They are suitable for preventing the genesis of high blood pressure.

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