Pyridino[2,3-d]pyrimidine derivatives as selective kdr and...

Details Pyridino[2,3-d]pyrimidine derivatives as selective kdr and... Pyridino[2,3-d]pyrimidine derivatives as selective kdr and...

C - Chemistry, Metallurgy

07

D

C07D 471/04 (2006.01) A61K 31/505 (2006.01) A61K 31/519 (2006.01) C07D 239/48 (2006.01)

Patent

CA 2508951

Disclosed are novel dihydropridinone compounds of the formula (I) wherein Ar, Ar' and R1 are as defined in the description, that are selective inhibitors of both KDR and FGFR kinases. These compounds and their pharmaceutically acceptable salts are anti-proliferative agents useful in the treatment or control of solid tumors, in particular breast, colon lung and prostate tumors. Also, disclosed are pharmaceutical compositions containing these compounds and their preparation.

Cette invention se rapporte à de nouveaux composés de dihydropyridinone, représentés par la formule (I), où Ar, Ar' et R?1¿ sont tels que définis dans les pièces descriptives de la demande, ces composés constituant des inhibiteurs sélectifs à la fois des KDR et des FGFR kinases. Ces composés et leurs sels acceptables sur le plan pharmaceutique constituent des agents antiprolifératifs utiles dans le traitement ou la lutte contre les tumeurs solides, notamment les tumeurs du sein, du colon, du poumon et de la prostate. Cette invention décrit également des compositions pharmaceutiques contenant ces composés et leur préparation.

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