C - Chemistry – Metallurgy – 12 – N
Patent
C - Chemistry, Metallurgy
12
N
C12N 7/04 (2006.01) A61K 39/205 (2006.01) A61P 31/14 (2006.01) C07K 14/145 (2006.01) A61K 39/00 (2006.01)
Patent
CA 2352231
The present invention relates to recombinant rabies virus mutants comprising a mutation in the viral genome, whereby said mutation comprises at least a substitution of the Arg333 codon in the gene encoding the G protein with a codon that differs by three nucleotides from said Arg333 codon. These rabies virus mutants have a glycoprotein G that comprises an amino acid at position 333 which is encoded by a codon that differs by all three nucleotides from the Arg codon in amino acid position 333 in the glycoprotein of the parental virus. Said recombinant rabies virus mutants are stable and non-pathogenic in immune competent animals and are suitable for use in a live, attenuated anti-rabis vaccine.
La présente invention porte sur des mutants du virus de la rage recombinants comprenant une mutation dans le génome viral. Cette mutation comprend au moins une substitution du codon Arg¿333? dans le gène codant la protéine G avec un codon qui diffère par trois nucléotides du codon Arg¿333?. Ces mutants du virus de la rage possèdent une glycoprotéine G codée par un codon qui diffère par les trois nucléotides du codon Arg¿333? à la position 333 des acides aminés de la glycoprotéine du virus parental. Ces mutants du virus de la rage recombinants sont stables et non pathogènes chez les animaux immunocompétents et sont appropriés pour être utilisés dans un vaccin antirabique atténué, vivant.
Conzelmann Karl Klaus
Mebatsion Teshome
Akzo Nobel N.v.
Fetherstonhaugh & Co.
Intervet International B.v.
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