Heterocyclic compounds useful as inhibitors of tyrosine kinases

Details Heterocyclic compounds useful as inhibitors of tyrosine kinases Heterocyclic compounds useful as inhibitors of tyrosine kinases

C - Chemistry, Metallurgy

07

D

C07D 487/04 (2006.01) A61K 31/517 (2006.01) C07D 235/30 (2006.01) C07D 239/88 (2006.01) C07D 239/96 (2006.01)

Patent

CA 2417635

Disclosed are novel compounds of formula (I) (see formula I as described in specification) wherein Ar1, X, Y, P, Q and Het are defined herein, which are useful as inhibitors of certain protein tyrosine kinases and are thus useful for treating diseases resulting from inappropriate cell proliferation, which include autoimmune diseases, chronic inflammatory diseases, allergic diseases, transplant rejection and cancer, as well as conditions resulting from cerebral ischemia, such as stroke. Also disclosed are pharmaceutical compositions comprising these compounds, processes for preparing these compounds and novel intermediate compounds useful in these processes.

L'invention concerne de nouveaux composés de formule (I) (formule décrite dans les spécifications) dans laquelle Ar¿1?, X,Y, P, Q et Het sont tels que définis dans la présente invention. Les composés sont utiles en tant qu'inhibiteurs de certaines protéines tyrosine kinases et donc utiles dans le traitement de maladies induites par une prolifération cellulaire anormale, telles que des maladies auto-immunes, des maladies inflammatoires chroniques, des maladies allergiques, le rejet de greffes et le cancer, ainsi que des conditions provenant d'une ischémie cérébrale, telles que les accidents vasculaires cérébraux. L'invention concerne également des compositions pharmaceutiques renfermant ces composés, des processus de préparation des composés et de nouveaux composés intermédiaires utiles dans ces processus.

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