Modified compstatin with peptide backbone and c-terminal...

Details Modified compstatin with peptide backbone and c-terminal... Modified compstatin with peptide backbone and c-terminal...

A - Human Necessities

61

K

A61K 38/04 (2006.01) C07K 7/64 (2006.01)

Patent

CA 2760839

Compounds comprising peptides capable of binding C3 protein and inhibiting complement activation are disclosed. These compounds display greatly improved complement activation-inhibitory activity as compared with currently available compounds. The compounds comprise compstatin analogs having a constrained backbone at position 8 (glycine) and, optionally, specific substitutions for threonine at position 13.

L'invention porte sur des composés comprenant des peptides capables de lier une protéine C3 et d'inhiber une activation du complément. Ces composés présentent une activité inhibitrice de l'activation du complément grandement améliorée par comparaison avec les composés disponibles actuellement. Les composés comprennent des analogues de compstatine ayant un squelette contraint en position 8 (glycine) et, facultativement, des substitutions spécifiques pour la thréonine en position 13.

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