C - Chemistry – Metallurgy – 07 – F
Patent
C - Chemistry, Metallurgy
07
F
C07F 9/30 (2006.01) A61K 31/662 (2006.01) A61P 19/08 (2006.01) A61P 27/06 (2006.01)
Patent
CA 2380326
The invention provides novel Prostaglandin F analogs. In particular, the present invention is directed to compounds having a structure according to formula (I) wherein R1, R z, X, Y, V, a, b, W, and Z are defined below. This invention also includes optical isomers, diastereomers and enantiomers of the formula, and pharmaceutically-acceptable salts, biohydrolyzable amides, esters, and imides thereof. The compounds of the present invention are useful for the treatment of a variety of diseases and conditions, such as bone disorders and glaucoma. Accordingly, the invention further provides pharmaceutical compositions comprising these compounds. The invention still further provides methods of treatment for bone disorders and glaucoma using these compounds or the compositions containing them.
La présente invention concerne de nouveaux analogues de prostaglandine F. En particulier, cette invention concerne des composés dont la structure est représentée par la formule (I) dans laquelle R1, R2, X, Y, V, a, b, W, et Z sont définis ci-dessous. En outre, cette invention comprend des isomères optiques, des diastéréoisomères et énantiomères de la formule, des sels acceptables sur le plan pharmaceutique, des amides biohydrolysables, des esters, et des imides de ceux-ci. Les composés de cette invention sont utilisés dans le traitement de maladies et d'états pathologiques variées, tels que les troubles osseux ou le glaucome. De même, cette invention concerne des compositions pharmaceutiques contenant ces composés. En outre, cette invention concerne des méthodes de traitement des troubles osseux et du glaucome utilisant ces composés ou les compositions qui les renferment.
De Biswanath
Delong Mitchell Anthony
Ebetino Frank Hallock
Wos John August
Duke University
Ledgley Law
The Procter & Gamble Company
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