Antibodies to cd40

Details Antibodies to cd40 Antibodies to cd40

C - Chemistry, Metallurgy

12

N

C12N 15/13 (2006.01) A01K 67/027 (2006.01) A61K 39/395 (2006.01) A61K 48/00 (2006.01) A61P 35/00 (2006.01) C07K 16/28 (2006.01) C12N 15/63 (2006.01) C12P 21/08 (2006.01)

Patent

CA 2466128

The present invention relates to antibodies and antigen-binding portions thereof that specifically bind to CD40, preferably human CD40, and that function as CD40 agonists. The invention also relates to human anti-CD40 antibodies and antigen-binding portions thereof. The invention also relates to antibodies that are chimeric, bispecific, derivatized, single chain antibodies or portions of fusion proteins. The invention also relates to isolated heavy and light chain immunoglobulins derived from human anti-CD40 antibodies and nucleic acid molecules encoding such immunoglobulins. The present invention also relates to methods of making human anti-CD40 antibodies, compositions comprising these antibodies and methods of using the antibodies and compositions for diagnosis and treatment. The invention also provides gene therapy methods using nucleic acid molecules encoding the heavy and/or light immunoglobulin molecules that comprise the human anti-CD40 antibodies. The invention also relates to transgenic animals comprising nucleic acid molecules of the present invention.

La présente invention concerne: des anticorps et des parties de liaison à l'antigène de celui-ci, qui se lient spécifiquement à CD40, de préférence à CD40 humain, et qui jouent le rôle d'agonistes de CD40; des anticorps humains anti-CD40 et leurs parties de liaison à l'antigène; des anticorps qui sont des anticorps chimères, bispécifiques, dérivés, à simple chaîne ou des parties de protéines de fusion; des immunoglobulines isolées à chaîne lourde et à chaîne légère dérivées des anticorps humains anti-CD40 et des molécules d'acide nucléique codant pour lesdites immunoglobulines; des procédés pour produire des anticorps humains anti-CD40, des compositions comprenant ces anticorps et des procédés d'utilisation des anticorps et des compositions à des fins de diagnostic et de traitement; des procédés de thérapie génique faisant intervenir l'utilisation de molécules d'acide nucléique codant pour des molécules d'immunoglobuline à chaîne lourde et/ou à chaîne légère qui comprennent les anticorps anti-CD40; des animaux transgéniques comprenant des molécules d'acide nucléique de l'invention.

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