Use of cephem derivatives as anti-metastatic agents

Details Use of cephem derivatives as anti-metastatic agents Use of cephem derivatives as anti-metastatic agents

A - Human Necessities

61

K

A61K 38/06 (2006.01) A61K 31/545 (2006.01) A61K 38/05 (2006.01) C07D 501/00 (2006.01)

Patent

CA 2167194

The present invention relates to the use of known cephem derivatives of formula (I), wherein n is zero, one or two; R1 is hydrogen or an organic radical, R2 represents halo or an organic radical or R1 and R2 taken together with the C-2 carbon atom of the cephem nucleus constitute a carbocyclic or heterocyclic group; R3 represents R2 as defined above or an organic radical, R4 is either R1 or an organic group, R5 is either R1 as defined above or halo or C1-C6 alkoxy, C1-C6 alkylthio or C1-C6 acylamino; R6 is R2 as defined above or an organic group, or pharmaceutically acceptable salt thereof.

L'invention concerne l'utilisation de dérivés connus de céphème répondant à la formule (I), dans laquelle n vaut zéro, un ou deux; R<1> représente hydrogène ou un radical organique; R<2> représente halog ou un radical organique, ou bien R<1> et R<2> pris ensemble avec l'atome de carbone C-2 du noyau céphème constituent un groupe carbocyclique ou hétérocycle; R<3> représente R<2> comme défini ci-dessus ou un radical organique; R<4> représente soit R<1> soit un groupe organique; R<5> représente soit R<1> comme défini ci-dessus ou halog ou alcoxy C1-C6, alkylthio C1-C6 ou acylamino C1-C6; R<6> représente R<2> tel que défini ci-dessus ou un groupe organique. L'invention concerne également des sels pharmaceutiquement acceptables desdits dérivés.

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