Thermally-gelling ophthalmic drug delivery vehicles...

Details Thermally-gelling ophthalmic drug delivery vehicles... Thermally-gelling ophthalmic drug delivery vehicles...

A - Human Necessities

61

K

A61K 47/38 (2006.01) A61K 9/00 (2006.01) A61K 9/06 (2006.01)

Patent

CA 2172373

Drug delivery vehicles which reversibly increase in either loss modulus or storage modulus, or both, upon contact with the eye, skin, mucous membrane or body cavity are disclosed. The vehicles contain one or more nonionic substituted cellulose ethers and do not require a charged sufactant or a pH-sensitive polymer for such increase in loss modulus or storage modulus, or both, upon administration. In one embodiment, the vehicles gel upon instillation in the eye.

L'invention concerne des excipients présentant une augmentation réversible du module de perte ou du module de conservation, ou des deux, lors du contact avec l'oeil, la peau, les muqueuses ou les cavités du corps. Ces excipients contiennent un ou plusieurs éthers cellulosiques substitués non ioniques et ne nécessitent pas un tensioactif chargé ou un polymère sensible au pH pour une telle augmentation du module de perte ou du module de conservation, ou des deux lors de l'administration. Dans un mode de réalisation, ces excipients se gélifient lors de l'instillation dans l'oeil.

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