C - Chemistry – Metallurgy – 07 – D
Patent
C - Chemistry, Metallurgy
07
D
C07D 409/06 (2006.01) A61K 31/40 (2006.01) A61K 31/41 (2006.01) A61K 31/44 (2006.01) A61K 31/495 (2006.01) C07D 209/34 (2006.01) C07D 209/60 (2006.01) C07D 209/70 (2006.01) C07D 401/06 (2006.01) C07D 405/06 (2006.01) C07D 409/14 (2006.01) C07D 413/06 (2006.01) C07D 417/06 (2006.01) C07D 491/04 (2006.01) C07D 495/04 (2006.01)
Patent
CA 2281050
Nitric oxide releasing oxindole prodrugs are described which are useful in methods of treating or preventing pain, inflammation, fever, or gastrointestinal lesions in a patient in need of such treatment, or of modifying an inflammatory disease or condition by favorably affecting the outcome thereof in said patient, wherein there is administered to said patient a therapeutically effective amount of a compound of Formula (I): (see formula I) and pharmaceutically acceptable salts thereof. In preferred embodiments, X is a covalent bond; R A and R B are both hydrogen; n is the integer 4; Y is -O-; Z is - NO2; R C is a member selected from the group consisting essentially of 5-Cl and 5-F; R O is a member selected from the group consisting essentially of 6-Cl and 6-F; and R E is a member selected from the group consisting essentially of benzyl, 2-furyl, 2-thienyl, 5-chloro-2-thienyl and 5-trifluoromethyl-2-thienyl.
Clark Michael Thomas
Lundy Kristin Marie
Pfizer Products Inc.
Smart & Biggar
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