Neuroblastoma-associated regulator gene

Details Neuroblastoma-associated regulator gene Neuroblastoma-associated regulator gene

C - Chemistry, Metallurgy

12

N

C12N 15/12 (2006.01) C07K 14/47 (2006.01) C07K 14/62 (2006.01) C07K 16/18 (2006.01) C12Q 1/68 (2006.01)

Patent

CA 2117293

2117293 9313205 PCTABS00024 Described is a gene situated in the region of the neuroblastoma consensus deletion 1p36.2-p36.1 and which codes for a helix-loop-helix protein with the designation HEIR-1. The gene is affected significantly by allelic tumour deletions in neuroblastomas and correlates inversely both with N-myc overexpression in tumours and with N-myc expression in normal development. The cDNA and antibodies coding for HEIR-1 are used for the diagnosis of pathological conditions associated with aberrations in the region of the neuroblastoma consensus deletion.

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