Nitric oxide releasing selective cyclooxygenase-2 inhibitors

Details Nitric oxide releasing selective cyclooxygenase-2 inhibitors Nitric oxide releasing selective cyclooxygenase-2 inhibitors

C - Chemistry, Metallurgy

07

D

C07D 261/08 (2006.01) A61K 31/415 (2006.01) A61K 31/42 (2006.01) C07D 231/12 (2006.01)

Patent

CA 2503063

The invention encompasses novel compounds of Formula (I) and Formula (II), which are nitric oxide-releasing prodrugs useful in the treatment of cyclooxygenase-2 mediated diseases. The invention also encompasses certain pharmaceutical compositions and methods for treatment of cyclooxygenase-2 mediated diseases comprising the use of compounds of Formula (I) or Formula (II). The above compounds may be used as a combination therapy with low-dose aspirin to treat chronic cyclooxygenase-2 mediated diseases or conditions while simultaneously reducing the risk of thrombotic cardiovascular events.

La présente invention concerne de nouveaux composés représentés par la formule (I) et la formule (II) qui sont des promédicaments libérant de l'oxyde nitrique utiles dans le traitement des maladies induites par la cyclo-oxygénase-2. Cette invention se rapporte également à certaines compositions pharmaceutiques et à certaines méthodes de traitement des maladies induites par la cyclo-oxygénase-2 dans lesquelles on utilise des composés représentés par la formule (I) ou (II). Lesdits composés peuvent être utilisés dans le cadre d'une polythérapie avec une faible dose d'aspirine pour traiter les maladies ou les états chroniques induits par la cyclo-oxygénase-2 tout en réduisant simultanément le risque d'événements cardiovasculaires thrombotiques. Formules (I) et (II)

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