Acridinium compounds and conjugates thereof

Details Acridinium compounds and conjugates thereof Acridinium compounds and conjugates thereof

C - Chemistry, Metallurgy

07

D

C07D 219/00 (2006.01) C07D 219/04 (2006.01) C07D 401/12 (2006.01) C12Q 1/68 (2006.01) G01N 33/52 (2006.01) G01N 33/53 (2006.01)

Patent

CA 2114754

ABSTRACT Acridinium compounds represented by the general formula (I) where A is an intervening group which does not have activity for binding with a specific binding substance, Z is a labelling active group which has activity for binding with a specific binding substance, R1 is a halogen atom, an alkyl group or an aryl group; R2, R3, R4 and R5 are each a hydrogen atom, an alkyl group, an aryl group, an alkoxy group, a nitro group, a halogen atom or a carbonyl group, and Y is a counter ion. The acridinium compounds may form conjugates with specific binding substances. The acridinium compounds have high emission efficiency and stability and, hence, are useful as chemiluminescence labelling agents.

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