Bifunctional antibodies and their use in targeting...

Details Bifunctional antibodies and their use in targeting... Bifunctional antibodies and their use in targeting...

C - Chemistry, Metallurgy

07

K

C07K 16/30 (2006.01) A61K 39/395 (2006.01) C07K 16/18 (2006.01)

Patent

CA 2341753

A bifunctional antibody has affinity for a target site and affinity for an organic molecule covalently linked to a cytotoxic agent or an enzyme capable of converting a prodrug into its cytotoxic form. The antibody may be used in therapy or diagnosis, especially in the treatment of tumours.

L'invention porte sur un anticorps bifonctionnel ayant une affinité pour un site cible et une affinité pour une molécule organique liée de manière covalente à un agent cytotoxique ou une enzyme capable de transformer un promédicament sous sa forme cytotoxique. L'anticorps peut être utilisé dans des procédés thérapeutiques ou diagnostiques, notamment dans le traitement des tumeurs.

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