C - Chemistry – Metallurgy – 07 – D
Patent
C - Chemistry, Metallurgy
07
D
C07D 471/04 (2006.01) A61K 31/437 (2006.01) A61P 3/00 (2006.01)
Patent
CA 2617102
The present application describes compounds, including all pharmaceutically acceptable salts, prodrugs, solvates and stereoisomers thereof, according to Formula (I), pharmaceutical compositions, comprising at least one compound according to Formula (I) and optionally at least one additional therapeutic agent and methods of treating various diseases, conditions and disorders associated with modulation of serotonin receptors such as, for example: metabolic diseases, which includes but is not limited to obesity, diabetes, diabetic complications, atherosclerosis, impared glucose tolerance and dyslipidemia; central nervous system diseases which includes but is not limited to, anxiety, depression, obsessive compulsive disorder, panic disorder, psychosis, schizophrenia, sleep disorder, sexual disorder and social phobias; cephalic pain; migraine; and gastrointestinal disorders using compounds according to Formula (I)
La présente invention concerne des composés, notamment la totalité des sels pharmaceutiquement acceptables, des promédicaments, des solvats et des stéréoisomères de ceux-ci, selon la formule I, les compositions pharmaceutiques, comprenant au moins un composé selon la formule I et facultativement au moins un agent thérapeutique supplémentaire ainsi que les procédés de traitement, au moyen d eces composés de formule (I), de diverses maladies et troubles associés à la modulation des récepteurs de sérotonine tels que, par exemple: les maladies métaboliques, ce qui inclut mais sans s'y limiter l'obésité, le diabète, les complications diabétiques, l'athérosclérose, la diminution de la tolérance au glucose et la dyslipidémie; les maladies du système nerveux central, ce qui inclut mais sans s'y limiter, l'anxiété, la dépression, les troubles obsessionnels compulsifs, la panique, la psychose, la schizophrénie, les troubles du sommeil, les troubles sexuels et les phobies sociales; les céphalées; la migraine ainsi que les troubles gastro-intestinaux.
Lee Taekyu
Bristol-Myers Squibb Company
Gowling Lafleur Henderson Llp
LandOfFree
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