Use of non-ionic cloud point modifiers to minimize...

Details Use of non-ionic cloud point modifiers to minimize... Use of non-ionic cloud point modifiers to minimize...

A - Human Necessities

61

K

A61K 49/04 (2006.01) A61K 9/14 (2006.01) A61K 9/51 (2006.01) A61K 47/48 (2006.01) B01F 17/00 (2006.01) B01J 13/02 (2006.01)

Patent

CA 2107694

ABSTRACT This invention discloses a composition comprised of nanoparticles having a surface modifier adsorbed on the surface thereof and a non-ionic cloud point modifier associated therewith, which cloud point modifier is present in an amount sufficient to increase the cloud point of the surface modifier. A preferred surface modifier is a poloxamine such as Tetronic 908, and preferred non-ionic cloud point modifiers include polyethylene glycol, propylene glycol, ethanol, hydroxypropylcyclodextrin and/or glycerol. This invention further discloses a method of making nanoparticles having a surface modifier adsorbed on the surface and a non-ionic cloud point modifier associated therewith, comprised of contacting said nanoparticles with the cloud point modifier for a time and under conditions sufficient to increase the cloud point of the surface modifier.

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