Novel aryl potassium channel blockers and uses thereof

Details Novel aryl potassium channel blockers and uses thereof Novel aryl potassium channel blockers and uses thereof

C - Chemistry, Metallurgy

07

C

C07C 217/52 (2006.01) A61K 31/397 (2006.01) A61K 31/40 (2006.01) A61K 31/415 (2006.01) A61K 31/4196 (2006.01) A61K 31/4402 (2006.01) A61K 31/4453 (2006.01) A61K 31/45 (2006.01) A61K 31/4965 (2006.01) A61K 31/5375 (2006.01) A61K 31/54 (2006.01) A61P 37/06 (2006.01) C07C 211/27 (2006.01) C07D 205/08 (2006.01) C07D 207/10 (2006.01) C07D 211/38 (2006.01) C07D 211/46 (2006.01) C07D 211/74 (2006.01) C07D 213/30 (2006.01) C07D 233/60 (2006.01) C07D 241/18 (2006.01) C07D 249/08 (2006.01) C07D 265/30 (2006.01) C07D

Patent

CA 2701579

The present invention relates to compounds useful in the modulation of potassium channel activity in cells, in par-ticular the activity of Kv1.3 channels found in T cells. The invention also relates to the use of these compounds in the treatment or prevention of autoimmune and inflammatory diseases, including multiple sclerosis, pharmaceutical compositions containing these compounds and methods for their preparation.

La présente invention concerne des composés utiles dans la modulation de l'activité des canaux potassiques dans les cellules, en particulier l'activité des canaux Kv1.3 qui se trouvent dans les lymphocytes T. L'invention concerne également l'utilisation de ces composés dans le traitement ou la prévention de maladies auto-immunes et inflammatoires, notamment la sclérose en plaques, des compositions pharmaceutiques contenant ces composés et des procédés pour les préparer.

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