Sustained release drug formulations containing a carrier...

Details Sustained release drug formulations containing a carrier... Sustained release drug formulations containing a carrier...

A - Human Necessities

61

K

A61K 9/06 (2006.01) A61K 9/00 (2006.01) A61K 9/19 (2006.01) A61K 9/22 (2006.01) A61K 31/13 (2006.01) A61K 31/4045 (2006.01) A61K 31/428 (2006.01) A61K 31/473 (2006.01) A61K 31/48 (2006.01) A61K 31/4985 (2006.01) A61K 38/09 (2006.01) A61K 38/23 (2006.01) A61K 38/24 (2006.01) A61K 38/25 (2006.01) A61K 38/29 (2006.01) A61K 38/31 (2006.01) A61K 47/10 (2006.01) A61K 47/26 (2006.01) A61K 47/42 (2006.01)

Patent

CA 2474613

The invention features a method of administering one or more therapeutic agents to a patient and delivering said agent or agents continuously over an extended period of time, said method comprising: obtaining a pharmaceutical composition including a peptide carrier, one or more therapeutic agents, and up to 30 percent, by weight, of a pharmaceutically acceptable, soluble, monomeric carrier; and parenterally administering said pharmaceutical composition to a subject by injection, wherein said composition automatically forms a gel after interaction with the patient's bodily fluids and releases said peptide carrier and said agent or agents continuously within the patient over an extended period.

Cette invention concerne une méthode d'administration chez un patient d'un ou de plusieurs agents thérapeutiques en continu pendant un laps de temps prolongé. Cette méthode consiste à injecter à un sujet une composition pharmaceutique comprenant un peptide support, un ou plusieurs agents thérapeutique et jusqu'à 30 % en poids d'un vecteur monomère soluble acceptable au plan phramaceutique. Ladite composition forme automatiquement un gel après interaction avec les liquides organiques du patient et libère ledit peptide support et le ou les agents dans le corps du patient pendant un laps de temps prolongé.

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