Sphingomyelin, intermediates thereof and methods for...

Details Sphingomyelin, intermediates thereof and methods for... Sphingomyelin, intermediates thereof and methods for...

C - Chemistry, Metallurgy

07

F

C07F 9/6584 (2006.01) A61K 31/661 (2006.01) C07F 9/113 (2006.01)

Patent

CA 2552797

The invention concerns novel oxazaphospholanes, cyclic and acyclic, and to their use in the synthesis of sphingomyelin and sphingomyelin analogous as well as to synthetic sphingomyelins obtained therefrom. One group of oxazaphospholane according to the invention has the general formula (1) disclosed herein. Specifically, the invention provides the 2S, 3R stereoisomers of the disclosed oxazaphospholanes and sphingomyelins and synthetic methods for their preparation.

L'invention porte sur de nouvelles oxazaphospholanes, cycliques et acycliques et sur leur utilisation dans la synthèse d'analogues de la sphingomyéline, et sur de la sphingomyéline de synthèse en dérivant. L'un des groupes d'oxazaphospholane de l'invention présente la formule (1). L'invention porte spécifiquement sur les stéréoisomères 2S, 3R des oxazaphospholanes et sphingomyélines de l'invention, et sur leur méthodes de préparation par synthèse.

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