Novel receptor protein and its use

Details Novel receptor protein and its use Novel receptor protein and its use

C - Chemistry, Metallurgy

07

K

C07K 14/715 (2006.01) C07K 14/705 (2006.01) C07K 16/28 (2006.01) G01N 33/566 (2006.01) A61K 38/00 (2006.01)

Patent

CA 2229449

A receptor protein derived from human dendritic cell, its partial peptide and their salts are disclosed. A production process of the receptor protein, an antibody against the receptor protein, a method for determination of a ligand to the receptor protein, a screening method and a screening kit for a compound which alters binding properties between a ligand and the receptor protein as well as a pharmaceutical composition of such compound are also disclosed. The receptor protein derived from human dendritic cell, its partial peptide and their salts are useful as reagents for screening ligands, agonists, antagonists and the like. The antibody is useful as a reagent for quantitative analysis of the receptor protein in a specimen fluid.

Divulgation d'une protéine réceptrice provenant des cellules dendritiques humaines, d'un peptide partiel de cette protéine et de leurs sels. Un procédé de production de la protéine réceptrice, un anticorps dirigé contre la protéine réceptrice, une méthode de détermination d'un ligand à la protéine réceptrice, une méthode et une trousse de criblage d'un composé qui modifie les propriétés de liaison entre un ligand et la protéine réceptrice, de même que la composition pharmaceutique d'un tel composé sont également dévoilés. La protéine réceptrice provenant de cellules dendritiques humaines, un peptide partiel de cette protéine et leurs sels sont utiles comme réactifs pour le criblage de ligands, d'agonistes, d'antagonistes et d'autres éléments du genre. L'anticorps sert de réactif dans l'analyse quantitative de la protéine réceptrice dans le fluide d'un échantillon.

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