Heteroaryl-substituted aminocyclohexane derivatives

Details Heteroaryl-substituted aminocyclohexane derivatives Heteroaryl-substituted aminocyclohexane derivatives

C - Chemistry, Metallurgy

07

D

C07D 213/60 (2006.01) A61K 31/435 (2006.01) A61K 31/495 (2006.01) A61P 3/00 (2006.01) C07D 213/74 (2006.01) C07D 213/85 (2006.01) C07D 237/20 (2006.01) C07D 237/22 (2006.01) C07D 239/28 (2006.01) C07D 239/42 (2006.01) C07D 401/04 (2006.01) C07D 409/04 (2006.01)

Patent

CA 2469380

The present invention relates to compounds of formula (I) wherein A1, A2, A3, A4, A5, A6, U, V, m, n and o are as defined in the description and claims, and pharmaceutically acceptable salts thereof. The compounds are useful for the treatment and/or prophylaxis of diseases which are associated with 2,3- oxidosqualenelanosterol cyclase such as hypercholesterolemia, hyperlipemia, arteriosclerosis, vascular diseases, mycoses, parasit infections, gallstones, tumors and/or hyperproliferative disorders, and treatment and/or prophylaxis of impaired glucose tolerance and diabetes.

la présente invention concerne des composés représentés par la formule (I) dans laquelle A?1¿, A?2¿, A?3¿, A?4¿, A?5¿, A?6¿, U, V, m, n et o sont conformes aux définitions qui en sont données dans le descriptif et les revendications, ainsi que des sels acceptables au plan pharmaceutique de ces dérivés. Ces dérivés conviennent pour le traitement et la prophylaxie de maladies associées à la 2,3-oxydosqualènelanostérol cyclase telles que l'hypercholestérolémie, l'hyperlipémie, l'artériosclérose, les maladies vasculaires, les mycoses, les infections parasitaires, les calculs biliaires, les tumeurs et/ou les troubles hyperprolifératifs ainsi que pour le traitement et/ou la prophylaxie de la diminution de tolérance au glucose et du diabète.

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