Phenyl-substituted 1,4-dihydropyridines

Details Phenyl-substituted 1,4-dihydropyridines Phenyl-substituted 1,4-dihydropyridines

C - Chemistry, Metallurgy

07

D

C07D 211/90 (2006.01) A61K 31/44 (2006.01) C07D 401/12 (2006.01)

Patent

CA 2137623

The invention provides compositions, uses and commercial packages for the treatment of a dementia or depression. The compounds of the invention have the general formula: (see formula I) wherein: R1 and R3 are identical or different and represent: (i) straight-chain or branched alkyl having up to 8 carbon atoms, which is optionally substituted by straight- chain or branched alkoxy having up to 6 carbon atoms or hydroxyl, or (ii) cycloalkyl having 3 to 7 carbon atoms; and R2 represents the radical: (see formula II) wherein: R4 and R5 are identical or different and represent a halogen atom, cyano, ethinyl, trifluoromethoxy, methyl, methylthio, trifluoromethyl, straight-chain or branched alkoxy having up to 4 carbon atoms or a hydrogen atom, with the proviso that R4 and R5 are not a hydrogen atom simultaneously; or a physiologically acceptable salt thereof.

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